ARIA
Adaptive Risk Intelligence for Polypharmacy Assessment
An AI agent system that does not just detect drug interactions. It reasons about them.
The Problem Nobody Has Solved
A $42 billion global crisis
Medication errors cost the world an estimated $42 billion USD every year. That is nearly 1% of total global health expenditure. Half of all preventable harm in medical care is medication-related.
The driver is polypharmacy: the simultaneous use of five or more medications. Global prevalence sits at 37% in the general population. It climbs to 52% among inpatients and 59% among frail elderly patients.
Existing tools are static lookup tables. They emit identical, context-free warnings for every patient. The result is predictable: clinicians override more than 90% of all drug interaction alerts. The tools designed to protect patients have become background noise.
What ARIA Does Differently
Not a drug interaction checker. A clinical reasoning engine.
N-Drug Interaction Graph
Full interaction graph with hub drug identification. Detects emergent 3-drug interactions invisible to pairwise checkers.
Temporal Cascade Modeling
Models when an interaction peaks, not just whether it exists. Predicts critical intervention windows.
Patient Phenotype Risk
Personalized risk score adjusted for age, CKD stage, hepatic function, sex, weight, and smoking status.
Deprescribing Optimizer
Prioritized, actionable plan: which drug to address first, what to substitute, expected risk reduction at each step.
8 Capabilities That Don't Exist Anywhere Else
Temporal Cascade Modeling
Predicts when risk peaks over time
Pharmacokinetic Reasoning
CYP enzyme, renal, microbiome pathways via Gemini 2.5 Pro
Patient Phenotype Multiplier
Same drugs, different patients, different risk scores
N-Drug Graph + Hub ID
Beyond pairwise. Finds the one drug causing 60% of conflicts.
Evidence Grading
A–D grades with confidence scores and PubMed citations
Cumulative Burden Scores
Anticholinergic, sedation, QT. Validated clinical metrics.
Deprescribing Optimizer
Not a warning. A plan with substitutes and timelines.
Integrated Pipeline
All 8 capabilities orchestrated into one coherent report
How It Works
Three steps to a clinical reasoning report
Enter Medications
Input the patient's medication list and clinical context: age, CKD stage, hepatic function, comorbidities.
AI Reasoning Pipeline
ARIA's agent orchestrates 8 tools: RxNorm normalization, interaction detection, phenotype scoring, temporal modeling, evidence grading, and more.
Actionable Report
Receive a 3D interactive clinical report with risk scores, deprescribing plans, evidence citations, and exportable PDF/HTML reports.
Technology Stack
Built By
One engineer. Three weeks. Eight clinical capabilities.
Wiqi Lee
Data Scientist · AI/ML Researcher · Software Engineer
“An agent that thinks like a clinical pharmacologist, not a database lookup.”
Submitted to the Agents Assemble: Healthcare AI Endgame Hackathon
Sponsored by Prompt Opinion (Darena Health)