ARIA
AdaptiveRiskIntelligenceforPolypharmacyAssessment

An AI agent system that goes beyond detecting drug interactions. It reasons through temporal modeling, mechanistic explanation, personalized risk scoring, and actionable deprescribing, all within a single integrated pipeline.

Eight Capabilities

Clinical reasoning features that do not exist in any other tool available today.

⏱

Temporal Cascade Modeling

Predicts when an interaction will peak, not just whether it exists.

🧬

Mechanistic Reasoning

Explains interactions at the molecular level through CYP pathways and renal clearance.

👤

Patient Phenotype Scoring

Calculates personalized risk adjusted for age, kidney function, and clinical history.

🕸

N-Drug Interaction Graph

Detects emergent three-drug interactions that pairwise checkers miss entirely.

📊

Evidence Grading

Tags every alert with a confidence score and links to PubMed citations.

🫘

Renal Dose Guidance

Flags drugs that need a dose reduction, avoidance, or monitoring for the patient's kidney function.

🩺

Geriatric Appropriateness

Screens older adults against Beers, STOPP, and START to surface inappropriate drugs and missing therapies.

💊

Deprescribing Optimizer

Generates a prioritized plan with substitutions and expected risk reduction at each step.

Ready to Analyze?

Enter a medication list and patient context. ARIA will reason through every interaction, calculate personalized risk, and generate a structured clinical report.